Did you know that even though our brain is only a small part of our body, it uses up a whopping one-fifth of all the energy we take in?
That's like a tiny city using as much power as a big metropolis!
In the effort to keep our mental "city" humming along and our thoughts razor-sharp, many have leaned on supplements and caffeine for that extra edge.
But there’s a new ingredient that’s getting a lot of attention: PQQ supplements.
People are excited about it because they think it might help us think better, remember more, and maybe even keep our brains young.
But here's the thing:
In a world where every other bottle on the supplement shelf promises to make us smarter or more focused, how do we know if PQQ is the real deal or just another tall tale?
Is PQQ a secret weapon for our brains, or is it just riding the hype train with no real ticket to greatness?
Let's unpack the facts and find out together.
What is PQQ?
Pyrroloquinoline Quinone, or PQQ was first identified as a cofactor for bacterial enzymes, substances that help speed up chemical reactions in the body.
Unlike most cofactors that are vitamins, PQQ was something new.
It was intriguing because it appeared to play a role in stimulating cellular growth, survival, and differentiation, particularly in the brain.
PQQ's most notable function is its ability to support the mitochondria, the powerhouse of our cells, thereby enhancing energy production and potentially safeguarding the neurons in our brain from damage.
PQQ Supplement Benefits and Brain Health
PQQ supplements have emerged as a fascinating subject for scientists due to their potential impact on cognitive function, neuroprotection, and energy levels.
Research spanning from animal models to human clinical trials provides a glimpse into the promising benefits of PQQ supplementation.
Cognitive Function Enhancement
Studies have consistently shown PQQ's positive effect on cognitive abilities.
One study on mice, highlighted in the "Journal of Nutrition," demonstrated significant improvements in memory and learning when PQQ was added to their diet. [1]
This improvement was attributed to enhanced mitochondrial function and increased levels of nerve growth factors, suggesting a strong link between PQQ intake and cognitive health.
In humans, a double-blind, placebo-controlled study with middle-aged and elderly participants found that PQQ supplementation led to better scores in tests for higher cognitive functions, especially attention and working memory, as reported in the "Journal of Nutritional Biochemistry." [2]
Neuroprotection
PQQ's ability to protect neurons from damage is particularly noteworthy.
Cell culture models have shown PQQ's capacity to safeguard neurons against oxidative stress and neurotoxicity, crucial factors in neurodegenerative diseases.
One study pointed out PQQ's role in inhibiting proteins linked to Parkinson's disease pathology, underlining its neuroprotective potential. [3]
Furthermore, PQQ has been observed to aid in brain recovery post-stroke in rats, reducing brain damage and fostering improved recovery outcomes, indicating its potential effectiveness in neuroregeneration and protection against ischemic injury. [4]
Energy and Overall Well-being
Beyond cognitive benefits, PQQ has shown promise in enhancing energy levels and overall well-being.
A study associated PQQ supplementation with improved sleep quality and mood by reducing fatigue and improving quality of life aspects such as appetite and sleep.
This suggests that PQQ could be a beneficial supplement for those seeking to mitigate fatigue without any health risks. [5]
Potential Side Effects and Considerations
Like any supplement, it's important to consider its safety profile, potential side effects, and appropriate dosages.
Known Side Effects
PQQ is generally considered safe when consumed in amounts found in foods.
As a supplement, PQQ has been used in various studies without significant adverse effects.
However, as with all supplements, individual reactions can vary, and some people might experience mild side effects, including:
Headaches: Some individuals may report mild headaches when beginning PQQ supplementation.
Gastrointestinal Discomfort: This can include mild nausea or digestive upset in certain individuals, especially when taken on an empty stomach.
Fatigue: Paradoxically, while PQQ is touted for its energy-boosting properties, a small number of individuals might experience fatigue, which could be related to individual metabolic responses.
It's worth noting that the reported side effects are typically mild and often resolve as the body adjusts to the supplement.
Recommended Dosages
The optimal dosage of PQQ has not been definitively established, and dosages in studies have varied.
Typically, doses range from 10 to 20 mg per day in human studies, which have demonstrated benefits without significant side effects.
Starting at the lower end of this range and observing your body's response can be a prudent approach to PQQ supplementation.
Choosing a PQQ Supplement
When selecting a PQQ supplement, consider the following factors to ensure quality and efficacy:
Purity and Quality: Look for supplements that specify the purity of PQQ and are free from unnecessary fillers or additives.
Reputable Brand: Choose a brand with a solid reputation for quality and transparency in their manufacturing processes.
Third-Party Testing: Supplements verified by independent third-party organizations for purity and potency offer an additional layer of trust.
Formulation: Some PQQ supplements are combined with other compounds, such as CoQ10, which may enhance mitochondrial function. Depending on your health goals, these combinations might offer additional benefits.
The Solution to Cognitive Fog and Memory Lapses
Do you find yourself struggling to keep up with the relentless pace of daily demands?
Are memory slips and lack of focus slowing you down, impacting your productivity and confidence?
In a world where mental sharpness is key to success, it's time to turn the tide with Neuro Thrive.
Neuro-Thrive is not just another brain supplement…
It's a scientifically formulated blend designed to address the very issues that hold you back.
With a powerful combination of PQQ, Alpha GPC, and Bacopa, Neuro Thrive targets the root of cognitive challenges, offering a pathway to enhanced memory, improved concentration, and sustained mental energy.
Imagine tackling your day with unwavering focus, retaining information with ease, and navigating through tasks with a clear and vibrant mind.
That's the promise of Neuro-Thrive.
Whether you're facing the pressures of a high-stakes career, academic pursuits, or simply striving for a mentally active and fulfilling life, Neuro Thrive is your ally.
Don't let cognitive fog and memory lapses define your potential.
Embrace the clarity, memory enhancement, and focus that Neuro Thrive offers.
References
- Ohwada K, Takeda H, Yamazaki M, Isogai H, Nakano M, Shimomura M, Fukui K, Urano S. Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats. J Clin Biochem Nutr. 2008 Jan;42(1):29-34. doi: 10.3164/jcbn.2008005. PMID: 18231627; PMCID: PMC2212345.
- Shiojima Y, Takahashi M, Takahashi R, Moriyama H, Bagchi D, Bagchi M, Akanuma M. Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. J Am Nutr Assoc. 2022 Nov-Dec;41(8):796-809. doi: 10.1080/07315724.2021.1962770. Epub 2021 Aug 20. Erratum in: J Am Nutr Assoc. 2022 Aug 2;:1. PMID: 34415830.
- Cheng, Q., Chen, J., Guo, H. et al. Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation. Acta Pharmacol Sin 42, 665–678 (2021). https://doi.org/10.1038/s41401-020-0487-2.
- Jonscher KR, Chowanadisai W, Rucker RB. Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention. Biomolecules. 2021 Sep 30;11(10):1441. doi: 10.3390/biom11101441. PMID: 34680074; PMCID: PMC8533503.
- Masahiko Nakano, Tetsuro Yamamoto, Hisayoshi Okamura, Akira Tsuda, and Yasuyuki Kowatari. Effects of Oral Supplementation withPyrroloquinoline Quinoneon Stress, Fatigue, and Sleep. Functional Foods in Health and Disease 2012, 2(8):307-324.